Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice....

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-05, Vol.296 (5571), p.1323-1326
Hauptverfasser:	Arase, Hisashi, Mocarski, Edward S., Campbell, Ann E., Hill, Ann B., Lanier, Lewis L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Analysis Animals Antigens, Ly - chemistry Antigens, Ly - genetics Antigens, Ly - immunology Antigens, Ly - metabolism Biological and medical sciences Cell interaction Cell interactions Cell Line Cell lines Cells Coculture Techniques Cytomegalovirus Cytomegaloviruses Disease Susceptibility Evolution, Molecular Fibroblasts Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Genetics Herpesviridae Infections - immunology Histocompatibility Antigens Class I - immunology Hybridomas Immune system Immunity, Innate Immunogenetics Interferon-gamma - biosynthesis killer cell inhibitory receptors Killer cells Killer Cells, Natural - immunology Lectins, C-Type Ligands Ly-49H antigen Lymphocyte Activation Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Inbred Strains Microbiology Murine cytomegalovirus Muromegalovirus - genetics Muromegalovirus - immunology Muromegalovirus - metabolism Natural killer cells NIH 3T3 cells NK Cell Lectin-Like Receptor Subfamily A Protein Binding Proteins Receptors Receptors, Immunologic - chemistry Receptors, Immunologic - genetics Receptors, Immunologic - immunology Receptors, Immunologic - metabolism Receptors, NK Cell Lectin-Like Recombinant Fusion Proteins - metabolism Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Structural Analysis (Linguistics) Structural Analysis (Science) T lymphocytes Transfection Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - immunology Viral Proteins - metabolism Virology Viruses
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Beschreibung
Zusammenfassung:	Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1070884