A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning domains was cloned by COS-7 expression using an opossum kidney cell complementary DNA (cDNA) library. The expressed receptor binds PTH a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1991-11, Vol.254 (5034), p.1024-1026
Hauptverfasser:	Jüppner, Harald, Abou-Samra, Abdul-Badi, Freeman, Mason, Kong, Xiang F., Schipani, Ernestina, Richards, Jennifer, Kolakowski, Lee F., Hock, Janet, Potts, John T., Kronenberg, Henry M., Segre, Gino V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Awards calcitonin Calcitonin receptors cDNA Complementary DNA COS cells Deoxyribonucleic acid DNA Endocrinology G proteins Genetics guanine nucleotide-binding protein Hormone receptors Hormones Kidney cells Ligands Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Molecular Sequence Data Nucleotides Opossums Parathyroid hormone Parathyroid Hormone - metabolism parathyroid hormone-related peptide Parathyroid Hormone-Related Protein Parathyroid hormones Proteins Proteins - metabolism Receptors Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Parathyroid Hormone Sequence Alignment Solubility Type 1 parathyroid hormone receptors
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Beschreibung
Zusammenfassung:	The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning domains was cloned by COS-7 expression using an opossum kidney cell complementary DNA (cDNA) library. The expressed receptor binds PTH and PTHrP with equal affinity, and both ligands equivalently stimulate adenylate cyclase. Striking homology with the calcitonin receptor and lack of homology with other G protein-linked receptors indicate that receptors for these calcium-regulating hormones are related and represent a new family.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1658941