New Plasmid-Mediated Phosphorylation of Gentamicin C in Staphylococcus aureus

New Plasmid-Mediated Phosphorylation of Gentamicin C in Staphylococcus aureus

A clinical isolate of Staphylococcus aureus resistant to gentamicin, kanamycin and 3′,4′‐dideoxykanamycin B contained two enzymes capable of inactivating gentamicin, i.e., an aminoglycoside 2″‐phosphotransferase and aminoglycoside acetyltransferase.

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Bibliographische Detailangaben
Veröffentlicht in:Microbiology and immunology 1978-09, Vol.22 (9), p.515-521
Hauptverfasser: Kawabe, Haruhide, Naganawa, Hiroshi, Kondo, Shinichi, Umezawa, Hamao, Mitsuhashi, Susumu
Format: Artikel
Sprache:eng
Schlagworte:
Acetyltransferases - metabolism
Aminoglycosides - pharmacology
Anti-Bacterial Agents - pharmacology
Cell-Free System
Gentamicins - metabolism
Humans
Phosphorylation
Phosphotransferases - metabolism
R Factors
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - metabolism
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Beschreibung
Zusammenfassung:A clinical isolate of Staphylococcus aureus resistant to gentamicin, kanamycin and 3′,4′‐dideoxykanamycin B contained two enzymes capable of inactivating gentamicin, i.e., an aminoglycoside 2″‐phosphotransferase and aminoglycoside acetyltransferase.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1978.tb00399.x