Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-05, Vol.300 (5624), p.1394-1399
Hauptverfasser:	Rota, Paul A., Oberste, M. Steven, Monroe, Stephan S., Nix, W. Allan, Campagnoli, Ray, Icenogle, Joseph P., Peñaranda, Silvia, Bankamp, Bettina, Maher, Kaija, Chen, Min-hsin, Tong, Suxiong, Tamin, Azaibi, Lowe, Luis, Frace, Michael, DeRisi, Joseph L., Chen, Qi, Wang, David, Erdman, Dean D., Teresa C. T. Peret, Burns, Cara, Ksiazek, Thomas G., Rollin, Pierre E., Sanchez, Anthony, Liffick, Stephanie, Holloway, Brian, Limor, Josef, McCaustland, Karen, Olsen-Rasmussen, Melissa, Fouchier, Ron, Günther, Stephan, Albert D. M. E. Osterhaus, Drosten, Christian, Pallansch, Mark A., Anderson, Larry J., Bellini, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Biological and medical sciences Causes of China Conserved Sequence Control Coronavirus Coronavirus - classification Coronavirus - genetics Coronaviruses Development and progression DNA DNA, Complementary Endopeptidases - chemistry Endopeptidases - genetics Epidemics Etiology Fundamental and applied biological sciences. Psychology Genetics Genome, Viral Genomes Genomics Hong Kong Humans Literary Devices Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Messenger RNA Microbiology Molecular Sequence Data Nucleocapsid Proteins - chemistry Nucleocapsid Proteins - genetics Observations Open Reading Frames Patients Phylogeny Polyproteins - chemistry Polyproteins - genetics Proteins Regulatory Sequences, Nucleic Acid RNA RNA Replicase - chemistry RNA Replicase - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - genetics SARS virus SARS Virus - chemistry SARS Virus - classification SARS Virus - genetics SARS Virus - isolation & purification Sequence Analysis, DNA Severe acute respiratory syndrome Severe Acute Respiratory Syndrome - virology Spike Glycoprotein, Coronavirus Transcription, Genetic Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Matrix Proteins - chemistry Viral Matrix Proteins - genetics Viral Proteins - chemistry Viral Proteins - genetics Virology Viruses
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Beschreibung
Zusammenfassung:	In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1085952