A Protein Antibiotic in the Phage Q[Beta] Virion: Diversity in Lysis Targets

A Protein Antibiotic in the Phage Q[Beta] Virion: Diversity in Lysis Targets

A2, a capsid protein of RNA phage Qbeta, is also responsible for host lysis. A2 blocked synthesis of murein precursors in vivo by inhibiting MurA, the catalyst of the committed step of murein biosynthesis.

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Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 2001-06, Vol.292 (5525), p.2326-2326
Hauptverfasser: Bernhardt, Thomas G, Wang, Ing-Nang, Struck, Douglas K, Young, Ryland
Format: Artikel
Sprache:eng
Schlagworte:
Bacteriophages
Biochemistry
DNA
Enzymes
Fractions
Genetic aspects
Genetics
Logical Thinking
Mutation
Proteins
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Zusammenfassung:A2, a capsid protein of RNA phage Qbeta, is also responsible for host lysis. A2 blocked synthesis of murein precursors in vivo by inhibiting MurA, the catalyst of the committed step of murein biosynthesis.
ISSN:0036-8075
1095-9203