Continuous expression of cancer-related fucosyl glycopeptides on the surface of human promyelocytic leukemia cells (HL-60) following terminal differentiation in vitro

The fucosyl glycopeptides on the surface of promyelocytic leukemia cells (HL-60) and normal human promyelocytes before and after differentiation and maturation were studied. The findings justify the conclusion that, although differentiation of human leukemia cells in vitro leads to an apparent norma...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1982-12, Vol.42 (12), p.5222-5230
Hauptverfasser:	van Beek, W P, Tulp, A, Egbers-Bogaards, M, Roozendaal, K J, Smets, L A
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow - physiopathology Cell Differentiation Cell Line Cell Membrane - physiology cell surface Fucose glycopeptides Glycopeptides - biosynthesis Glycoproteins - biosynthesis Humans Kinetics Leukemia, Myeloid, Acute - physiopathology man Membrane Proteins - biosynthesis Neoplasm Proteins - biosynthesis promylocytic leukemia
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Zusammenfassung:	The fucosyl glycopeptides on the surface of promyelocytic leukemia cells (HL-60) and normal human promyelocytes before and after differentiation and maturation were studied. The findings justify the conclusion that, although differentiation of human leukemia cells in vitro leads to an apparent normal maturation, these matured cells still carry glycopeptides on their surface exclusively found on malignant and certain premalignant cells. They may therefore, reflect the leukemic origin of the cells independent of their state of differentiation.
ISSN:	0008-5472