Concanavalin a binding of the cell surface of Duchenne muscle in vitro

Ultrastructural examination of concanavalin A (Con A) binding sites in cultured skeletal muscle from six patients with Duchenne muscular dystrophy (DMD) revealed no abnormalities at the cell surface when compared to normal cultured skeletal muscle. Reaction product at the cell surface appeared regular and continuous in both normal and dystrophic cultured muscle cells. These findings indicate that the abnormalities of Con A surface binding found in biopsied muscle of DMD are not present in aneurally cultured dystrophic muscle cells.