Study on Influence of Synthetic Glucagon Fragment on Lymphocyte Transformation. I

Study on Influence of Synthetic Glucagon Fragment on Lymphocyte Transformation. I

The tetradecapeptide corresponding to position 1 to 14 of glucagon was synthesized by a conventional method. Though the suppression test of this peptide was tested against PHA-induced lymphocyte transformation, any reproducible and significant results were not obtained. In this finding, the effect o...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1978/11/25, Vol.26(11), pp.3546-3551
Hauptverfasser: ABIKO, TAKASHI, KUMIKAWA, MIHOKO, DAZAI, SACHIKO, UNO, CHIKAKO, ISHIZAKI, MAKOTO, TAKAHASHI, HISASHI, SEKINO, HIROSHI
Format: Artikel
Sprache:eng
Schlagworte:
Glucagon - analogs & derivatives
Glucagon - pharmacology
Humans
Kidney Failure, Chronic - immunology
Lymphocyte Activation - drug effects
Peptide Fragments - chemical synthesis
Peptide Fragments - pharmacology
uremia
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Zusammenfassung:The tetradecapeptide corresponding to position 1 to 14 of glucagon was synthesized by a conventional method. Though the suppression test of this peptide was tested against PHA-induced lymphocyte transformation, any reproducible and significant results were not obtained. In this finding, the effect on immunodeficiency of chronic renal failure was not because of glucagon fragment (1-14).
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.26.3546