PRODUCTION AND BIOLOGICAL ACTIVITY OF MARCELLOMYCIN, AN ANTITUMOR ANTHRACYCLINE ANTIBIOTIC, AND TAXONOMY OF THE PRODUCING ORGANISM

PRODUCTION AND BIOLOGICAL ACTIVITY OF MARCELLOMYCIN, AN ANTITUMOR ANTHRACYCLINE ANTIBIOTIC, AND TAXONOMY OF THE PRODUCING ORGANISM

An actinomycete, isolated from a soil sample from Ontario, Canada, was studied taxonomically and named Actinosporangium bohemicum sp. nov. strain C-36, 145. This strain was found to produce a complex mixture of ε-pyrromycinone glycosides having antitumor properties. Marcellomycin, a member of this c...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of antibiotics 1982, Vol.35(9), pp.1174-1183
Hauptverfasser: BUSH, J. A., BRADNER, W. T., TOMITA, K.
Format: Artikel
Sprache:eng
Schlagworte:
Actinomycetales - classification
Actinomycetales - metabolism
Animals
Anthracyclines
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - therapeutic use
Cell Wall - metabolism
Culture Media
Escherichia coli - drug effects
Fermentation
Leukemia P388 - drug therapy
Mice
Naphthacenes - biosynthesis
Naphthacenes - therapeutic use
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An actinomycete, isolated from a soil sample from Ontario, Canada, was studied taxonomically and named Actinosporangium bohemicum sp. nov. strain C-36, 145. This strain was found to produce a complex mixture of ε-pyrromycinone glycosides having antitumor properties. Marcellomycin, a member of this complex, was selected for further study. Conditions for production of this antibiotic were developed in flask studies and scaled-up to the 3, 000-liter fermentor stage.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.35.1174