Elevation of serum prostaglandin E levels following electrical stimulation of the midbrain

Serum prostaglandin E (PGE) levels were measured in rats immediately following electrical stimulation of the mesencephalic periaqueductal gray (PAG) region and the nucleus raphe magnus (NRM) and compared to controls. An additional group received aspirin prior to PAG stimulation. A significant increa...

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Veröffentlicht in:	Journal of neuroimmunology 1982-11, Vol.3 (3), p.219-224
Hauptverfasser:	Rosshirt, W, Simon, R H, Shaskan, E G, Siok, C, Dore-Duffy, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin - pharmacology Electric Stimulation Female Mesencephalon - metabolism Periaqueductal Gray - metabolism Prostaglandin Antagonists - pharmacology Prostaglandins E - blood Raphe Nuclei - metabolism Rats Rats, Inbred Strains
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Zusammenfassung:	Serum prostaglandin E (PGE) levels were measured in rats immediately following electrical stimulation of the mesencephalic periaqueductal gray (PAG) region and the nucleus raphe magnus (NRM) and compared to controls. An additional group received aspirin prior to PAG stimulation. A significant increase in serum PGE levels was found after stimulation of the PAG, but not the NRM. Aspirin inhibited the stimulation-induced increases in PGE.
ISSN:	0165-5728
DOI:	10.1016/0165-5728(82)90024-8