Naloxone blocks the excitatory effect of ethanol and chlordiazepoxide on lateral hypothalamic self-stimulation behavior

Naloxone blocks the excitatory effect of ethanol and chlordiazepoxide on lateral hypothalamic self-stimulation behavior

Ethanol (ETOH, 0.5 g/kg) and chlordiazepoxide (CDP, 4.0 mg/kg) enhance operant responding by rats for lateral hypothalamic (LH) self-stimulation (SS). Naloxone (NOX, 5.0 mg/kg) does not affect LH SS or blood alcohol level, but prevents the increased responding for LH SS produced by ETOH and CDP. Thu...

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Veröffentlicht in:Life sciences (1973) 1978-10, Vol.23 (13), p.1359-1364
Hauptverfasser: Lorens, Stanley A., Sainati, Stephen M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chlordiazepoxide - antagonists & inhibitors
Ethanol - antagonists & inhibitors
Ethanol - blood
Hypothalamus - drug effects
Hypothalamus - physiology
Male
Naloxone - pharmacology
Rats
Self Stimulation - drug effects
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Zusammenfassung:Ethanol (ETOH, 0.5 g/kg) and chlordiazepoxide (CDP, 4.0 mg/kg) enhance operant responding by rats for lateral hypothalamic (LH) self-stimulation (SS). Naloxone (NOX, 5.0 mg/kg) does not affect LH SS or blood alcohol level, but prevents the increased responding for LH SS produced by ETOH and CDP. Thus, ETOH and CDP, but not brain stimulation reward itself, may release an endogenous opioid whose action at opiate receptors results in an excitatory behavioral (euphorigenic?) effect which can be blocked by NOX.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(78)90394-6