Antiviral activity of some .beta.-diketones. 4. Benzyl diketones. In vitro activity against both RNA and DNA viruses

The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be...

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Veröffentlicht in:	Journal of medicinal chemistry 1978-09, Vol.21 (9), p.889-894
Hauptverfasser:	Diana, G. D, Carabateas, Philip M, Johnson, Robert E, Williams, Gordon L, Pancic, Francis, Collins, Joseph C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - chemical synthesis Antiviral Agents - therapeutic use Benzyl Compounds - chemical synthesis Benzyl Compounds - pharmacology Benzyl Compounds - therapeutic use Culture Techniques DNA Viruses - drug effects Female Herpes Simplex - drug therapy Ketones - chemical synthesis Ketones - pharmacology Ketones - therapeutic use Mice Organ Culture Techniques RNA Viruses - drug effects
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Beschreibung
Zusammenfassung:	The synthesis and in vitro antiviral evaluation of a series of substituted benzyl beta-diketones are described. The introduction of a styryl group onto the phenyl ring enhanced activity against herpesvirus type 2. The 4-methoxystyryl homologue 8 was evaluated extensively in vitro and was found to be effective against both RNA and DNA viruses. Compound 8 was evaluated in the mouse vagina against herpes simplex type 1 and produced a significant increase in survival rate as well as in survival time.
ISSN:	0022-2623 1520-4804
DOI:	10.1021/jm00207a010