Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system
The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐...
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| Veröffentlicht in: | European journal of immunology 1982, Vol.12 (9), p.773-777 |
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| container_title | European journal of immunology |
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| creator | Gualde, Norbert Rabinovitch, Hélène Fredon, Monique Rigaud, Michel |
| description | The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐linked. HLA‐B12 subjects were less sensitive than non‐B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions. |
| doi_str_mv | 10.1002/eji.1830120913 |
| format | Article |
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It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐linked. HLA‐B12 subjects were less sensitive than non‐B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830120913</identifier><identifier>PMID: 7140815</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Adolescent ; Adult ; Animals ; Arachidonic Acids - pharmacology ; Concanavalin A - pharmacology ; Erythrocytes - immunology ; HLA Antigens ; Humans ; Immunosuppressive Agents ; In Vitro Techniques ; Leukotrienes ; Lipid Peroxides ; Lymphocyte Activation - drug effects ; Lymphocytes - drug effects ; Lymphocytes - immunology ; Rosette Formation ; Sheep</subject><ispartof>European journal of immunology, 1982, Vol.12 (9), p.773-777</ispartof><rights>Copyright © 1982 WILEY‐VCH Verlag GmbH & Co. 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It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐linked. HLA‐B12 subjects were less sensitive than non‐B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Animals</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Concanavalin A - pharmacology</subject><subject>Erythrocytes - immunology</subject><subject>HLA Antigens</subject><subject>Humans</subject><subject>Immunosuppressive Agents</subject><subject>In Vitro Techniques</subject><subject>Leukotrienes</subject><subject>Lipid Peroxides</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - immunology</subject><subject>Rosette Formation</subject><subject>Sheep</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtVBROxS27JC86i6DHccTZzmqBlo0EhtYR459o7hK7NTX0zY7PoFv4NP4EoxmVLpjdaXzujo6hLznbM0ZKz_CnVtzJRgvWcPFK7LisuRFxSt-RlaM8aooG8UuyBvEO8ZYs5HNOTmvecUUlyvya9f3YBLS0FMuf__4OSw2hhlieFrAmYA6QYoafHCGauMsDZ4Oh0l7Oi7TPASzJKA4AMwU4pKGeERiQEj59iFOOrls0t7SCDgHj0BToCZ4o71-0KPzdEs1YjAuf7P00aWB3uy3FBdMML0lr3s9Irw73Uvy_dPu2_VNsf_6-fZ6uy-MqJgolDGlUcChb6xgda2lqQVUXbeppTJdLiybvobGdhsrSpuRjYSsq5VmVggpLsnVMXeO4f4AmNrJoYFx1B7CAdu6KhWTimfh-ig0uSVG6Ns5uknHpeWs_TtKm0dp_42SDR9OyYduAvssP62Q-ebIP7oRlv-ktbsvty-y_wDaRp2o</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Gualde, Norbert</creator><creator>Rabinovitch, Hélène</creator><creator>Fredon, Monique</creator><creator>Rigaud, Michel</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system</title><author>Gualde, Norbert ; Rabinovitch, Hélène ; Fredon, Monique ; Rigaud, Michel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3403-8cc2c8e1ef9d3077a5c73e4bb6758cb14059f7e9db6d32dcb165e07778a0d3353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Animals</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Concanavalin A - pharmacology</topic><topic>Erythrocytes - immunology</topic><topic>HLA Antigens</topic><topic>Humans</topic><topic>Immunosuppressive Agents</topic><topic>In Vitro Techniques</topic><topic>Leukotrienes</topic><topic>Lipid Peroxides</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - immunology</topic><topic>Rosette Formation</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gualde, Norbert</creatorcontrib><creatorcontrib>Rabinovitch, Hélène</creatorcontrib><creatorcontrib>Fredon, Monique</creatorcontrib><creatorcontrib>Rigaud, Michel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gualde, Norbert</au><au>Rabinovitch, Hélène</au><au>Fredon, Monique</au><au>Rigaud, Michel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1982</date><risdate>1982</risdate><volume>12</volume><issue>9</issue><spage>773</spage><epage>777</epage><pages>773-777</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐linked. HLA‐B12 subjects were less sensitive than non‐B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>7140815</pmid><doi>10.1002/eji.1830120913</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1982, Vol.12 (9), p.773-777 |
| issn | 0014-2980 1521-4141 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adolescent Adult Animals Arachidonic Acids - pharmacology Concanavalin A - pharmacology Erythrocytes - immunology HLA Antigens Humans Immunosuppressive Agents In Vitro Techniques Leukotrienes Lipid Peroxides Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Rosette Formation Sheep |
| title | Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system |
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