Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system

The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐...

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Veröffentlicht in:	European journal of immunology 1982, Vol.12 (9), p.773-777
Hauptverfasser:	Gualde, Norbert, Rabinovitch, Hélène, Fredon, Monique, Rigaud, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Arachidonic Acids - pharmacology Concanavalin A - pharmacology Erythrocytes - immunology HLA Antigens Humans Immunosuppressive Agents In Vitro Techniques Leukotrienes Lipid Peroxides Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - immunology Rosette Formation Sheep
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Zusammenfassung:	The lipoxygenase product hydroperoxyeicosatetraenoic acid (HPETE) has immunosuppressive properties in vitro and in vivo. It was observed that 15‐HPETE inhibit the sheep red blood cell rosette formation and the concanavalin A‐induced blast transformation of human lymphocytes. This inhibition was HLA‐linked. HLA‐B12 subjects were less sensitive than non‐B12 subjects. It is likely that HPETE acids are macrophage mediators which inhibit some lymphocyte functions.
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.1830120913