Quantitation of the Anti-Inflammatory Agent Fenbufen and Its Metabolites in Human Serum and Urine Using High-pressure Liquid Chromatography

Specific procedures are described for the determination of fenbufen and its metabolites in serum and urine using high-pressure liquid chromatography. Serum or urine extracts were chromatographed on a bonded reversed-phase partitioning column. The sensitivity of the assay for fenbufen was 0.5μg/ml in...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1978-12, Vol.67 (12), p.1662-1664
Hauptverfasser:	Van Lear, G.E., Chiccarelli, F.S., Bonenfant, P.A., Barr, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Inflammatory Agents, Non-Steroidal - analysis Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - urine Anti-inflammatory agents-fenbufen Anti-inflammatory agentsfenbufen, high-pressure liquid chromatographic analysis in serum and urine Anti‐inflammatory agents—fenbufen, high‐pressure liquid chromatographic analysis in serum and urine Biphenyl Compounds - analysis Biphenyl Compounds - blood Biphenyl Compounds - urine Chromatography, High Pressure Liquid fenbufen in serum and urine Fenbufen-high-pressure liquid chromatographic analysis in serum and urine high-pressure liquid chromatographic analysis in serum and urine High-pressure liquid chromatography-analysis High-pressure liquid chromatographyanalysis, fenbufen in serum and urine High‐pressure liquid chromatography—analysis, fenbufen in serum and urine Humans Male Methods Propionates - analysis Propionates - blood Propionates - urine
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Beschreibung
Zusammenfassung:	Specific procedures are described for the determination of fenbufen and its metabolites in serum and urine using high-pressure liquid chromatography. Serum or urine extracts were chromatographed on a bonded reversed-phase partitioning column. The sensitivity of the assay for fenbufen was 0.5μg/ml in serum with 2-ml samples and 1.0μg/ml in urine with 1-ml samples. The procedures are suitable for bioavailability and pharmacokinetic studies.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600671206