Chemical occlusion of rhesus monkey oviducts with chloroquine

Fertility control through chemical occlusion of the oviducts with chloroquine was investigated in rhesus monkeys (M.m.). Chloroquine was instilled retrograde through the tubal ostium after laparotomising the monkeys as a 10, 50 and 100% suspension (w/v) in aqueous carboxymethyl cellulose (CMC) solut...

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Veröffentlicht in:	Contraception (Stoneham) 1978-09, Vol.18 (3), p.233-238
Hauptverfasser:	Chandra, Harish, Nigam, Satish Chandra, Zutshi, Shakti, Malaviya, Brajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chloroquine - pharmacology Dose-Response Relationship, Drug Female Haplorhini Macaca mulatta Oviducts - drug effects Oviducts - pathology
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Zusammenfassung:	Fertility control through chemical occlusion of the oviducts with chloroquine was investigated in rhesus monkeys (M.m.). Chloroquine was instilled retrograde through the tubal ostium after laparotomising the monkeys as a 10, 50 and 100% suspension (w/v) in aqueous carboxymethyl cellulose (CMC) solution which was used as a carrier vehicle. Complete occlusion of the Fallopian tubes at the uterotubal junction and also the intramural portions resulted in 15 days after a single instillation.
ISSN:	0010-7824 1879-0518
DOI:	10.1016/S0010-7824(78)80017-1