Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi
Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1982-10, Vol.218 (4569), p.288-289 |
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| container_end_page | 289 |
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| container_issue | 4569 |
| container_start_page | 288 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 218 |
| creator | Montamat, Enrique E. Burgos, Carlos Nelia M. Gerez De Burgos Rovai, Leonor E. Blanco, Antonio Segura, Elsa L. |
| description | Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture. |
| doi_str_mv | 10.1126/science.6750791 |
| format | Article |
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Gerez De Burgos ; Rovai, Leonor E. ; Blanco, Antonio ; Segura, Elsa L.</creator><creatorcontrib>Montamat, Enrique E. ; Burgos, Carlos ; Nelia M. Gerez De Burgos ; Rovai, Leonor E. ; Blanco, Antonio ; Segura, Elsa L.</creatorcontrib><description>Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6750791</identifier><identifier>PMID: 6750791</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Alcohol Oxidoreductases - metabolism ; Chagas disease ; Dehydrogenases ; Enzymes ; Epimastigotes ; Ethanol ; Gossypol - pharmacology ; L-Lactate Dehydrogenase ; Lactate Dehydrogenases ; Leukotrienes ; Lungs ; Malate Dehydrogenase - metabolism ; Oxidoreductases - metabolism ; Parasites ; Parasitic diseases ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - enzymology ; Trypanosoma cruzi - growth & development</subject><ispartof>Science (American Association for the Advancement of Science), 1982-10, Vol.218 (4569), p.288-289</ispartof><rights>Copyright 1982 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-26551f93ed698269437973c7099958bec8125aeba285451e468ec2a79e9b3b183</citedby><cites>FETCH-LOGICAL-c343t-26551f93ed698269437973c7099958bec8125aeba285451e468ec2a79e9b3b183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1689256$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1689256$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27926,27927,58019,58252</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6750791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montamat, Enrique E.</creatorcontrib><creatorcontrib>Burgos, Carlos</creatorcontrib><creatorcontrib>Nelia M. Gerez De Burgos</creatorcontrib><creatorcontrib>Rovai, Leonor E.</creatorcontrib><creatorcontrib>Blanco, Antonio</creatorcontrib><creatorcontrib>Segura, Elsa L.</creatorcontrib><title>Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.</description><subject>Alcohol Oxidoreductases - metabolism</subject><subject>Chagas disease</subject><subject>Dehydrogenases</subject><subject>Enzymes</subject><subject>Epimastigotes</subject><subject>Ethanol</subject><subject>Gossypol - pharmacology</subject><subject>L-Lactate Dehydrogenase</subject><subject>Lactate Dehydrogenases</subject><subject>Leukotrienes</subject><subject>Lungs</subject><subject>Malate Dehydrogenase - metabolism</subject><subject>Oxidoreductases - metabolism</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Trypanosoma cruzi - drug effects</subject><subject>Trypanosoma cruzi - enzymology</subject><subject>Trypanosoma cruzi - growth & development</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1rwkAQhpfSYq3tuZcWcuotuh_Zr6OIVUHoxZ7DZp1gJMna3YQSf30jhnoahveZF-ZB6JXgKSFUzIItoLYwFZJjqckdGhOseawpZvdojDETscKSP6KnEI4Y95lmIzQa8DFab-pDkRWN8100t03h6sjl0cqF0J1cGfXrsj53FYTI1Pto5d1vc7gQO9-dTO2Cq0xkfXsuntFDbsoAL8OcoO_P5W6xjrdfq81ivo0tS1gTU8E5yTWDvdCKCp0wqSWzEmutucrAKkK5gcxQxRNOIBEKLDVSg85YRhSboI9r78m7nxZCk1ZFsFCWpgbXhlQmNCGS0R6cXUHr-2885OnJF5XxXUpwenGXDu7SQUZ_8T5Ut1kF-3_-lr9d82Pofd3qhNKUC_YHJSp0Og</recordid><startdate>19821015</startdate><enddate>19821015</enddate><creator>Montamat, Enrique E.</creator><creator>Burgos, Carlos</creator><creator>Nelia M. Gerez De Burgos</creator><creator>Rovai, Leonor E.</creator><creator>Blanco, Antonio</creator><creator>Segura, Elsa L.</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19821015</creationdate><title>Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi</title><author>Montamat, Enrique E. ; Burgos, Carlos ; Nelia M. Gerez De Burgos ; Rovai, Leonor E. ; Blanco, Antonio ; Segura, Elsa L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-26551f93ed698269437973c7099958bec8125aeba285451e468ec2a79e9b3b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Alcohol Oxidoreductases - metabolism</topic><topic>Chagas disease</topic><topic>Dehydrogenases</topic><topic>Enzymes</topic><topic>Epimastigotes</topic><topic>Ethanol</topic><topic>Gossypol - pharmacology</topic><topic>L-Lactate Dehydrogenase</topic><topic>Lactate Dehydrogenases</topic><topic>Leukotrienes</topic><topic>Lungs</topic><topic>Malate Dehydrogenase - metabolism</topic><topic>Oxidoreductases - metabolism</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Trypanosoma cruzi - drug effects</topic><topic>Trypanosoma cruzi - enzymology</topic><topic>Trypanosoma cruzi - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montamat, Enrique E.</creatorcontrib><creatorcontrib>Burgos, Carlos</creatorcontrib><creatorcontrib>Nelia M. Gerez De Burgos</creatorcontrib><creatorcontrib>Rovai, Leonor E.</creatorcontrib><creatorcontrib>Blanco, Antonio</creatorcontrib><creatorcontrib>Segura, Elsa L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montamat, Enrique E.</au><au>Burgos, Carlos</au><au>Nelia M. Gerez De Burgos</au><au>Rovai, Leonor E.</au><au>Blanco, Antonio</au><au>Segura, Elsa L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1982-10-15</date><risdate>1982</risdate><volume>218</volume><issue>4569</issue><spage>288</spage><epage>289</epage><pages>288-289</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>6750791</pmid><doi>10.1126/science.6750791</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1982-10, Vol.218 (4569), p.288-289 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74241732 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Alcohol Oxidoreductases - metabolism Chagas disease Dehydrogenases Enzymes Epimastigotes Ethanol Gossypol - pharmacology L-Lactate Dehydrogenase Lactate Dehydrogenases Leukotrienes Lungs Malate Dehydrogenase - metabolism Oxidoreductases - metabolism Parasites Parasitic diseases Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Trypanosoma cruzi - growth & development |
| title | Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi |
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