Inhibitory Action of Gossypol on Enzymes and Growth of Trypanosoma cruzi

Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1982-10, Vol.218 (4569), p.288-289
Hauptverfasser:	Montamat, Enrique E., Burgos, Carlos, Nelia M. Gerez De Burgos, Rovai, Leonor E., Blanco, Antonio, Segura, Elsa L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - metabolism Chagas disease Dehydrogenases Enzymes Epimastigotes Ethanol Gossypol - pharmacology L-Lactate Dehydrogenase Lactate Dehydrogenases Leukotrienes Lungs Malate Dehydrogenase - metabolism Oxidoreductases - metabolism Parasites Parasitic diseases Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology Trypanosoma cruzi - growth & development
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide--linked enzymes (α-hydroxy-acid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6750791