Effect of disodium cromoglycate and cyclic amp-active drugs on cytotoxic histamine release from rat mast cells
Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor media...
Gespeichert in:
Veröffentlicht in: | Biochemical pharmacology 1982-07, Vol.31 (13), p.2247-2250 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor mediated calcium channels and alternative explanations of their action are considered. |
---|---|
ISSN: | 0006-2952 1873-2968 |
DOI: | 10.1016/0006-2952(82)90109-5 |