Effect of disodium cromoglycate and cyclic amp-active drugs on cytotoxic histamine release from rat mast cells

Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor media...

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Veröffentlicht in:Biochemical pharmacology 1982-07, Vol.31 (13), p.2247-2250
Hauptverfasser: Pearce, F.L., Clements, J.
Format: Artikel
Sprache:eng
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Zusammenfassung:Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor mediated calcium channels and alternative explanations of their action are considered.
ISSN:0006-2952
1873-2968
DOI:10.1016/0006-2952(82)90109-5