INHIBITION OF THROMBIN AND TRYPSIN BY TRIPEPTIDE ALDEHYDES

INHIBITION OF THROMBIN AND TRYPSIN BY TRIPEPTIDE ALDEHYDES

Inhibitory effects of certain tripeptide aldehydes on both thrombin and trypsin have been found to be strongly substrate‐dependent. These compounds should therefore be considered as inhibitors of the particular proteolytic reaction for which they had been designed rather than real enzyme inhibitors,...

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Veröffentlicht in:International Journal of Peptide and Protein Research 1978-10, Vol.12 (4), p.217-221
Hauptverfasser: Bajusz, S., Barabas, E., Tolnay, P., Szell, E., Bagdy, D.
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Peptides
substrate dependence
Thrombin - antagonists & inhibitors
thrombin inhibition
tripeptide aldehydes
trypsin inhibition
Trypsin Inhibitors
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Beschreibung
Zusammenfassung:Inhibitory effects of certain tripeptide aldehydes on both thrombin and trypsin have been found to be strongly substrate‐dependent. These compounds should therefore be considered as inhibitors of the particular proteolytic reaction for which they had been designed rather than real enzyme inhibitors, i.e. protein or polypeptide proteinase inhibitors of natural origin.
ISSN:0367-8377
1399-3011
DOI:10.1111/j.1399-3011.1978.tb02889.x