Cholesterol excretion and liver cholesterol in rats during early stages of orotic acid feeding

The early effects of orotic add on the concentration of plasma cholesterol, liver cholesterol, and fecal excretion of neutral sterols and bile acids were examined. Feeding rats 1% orotic acid for a week resulted in a decrease in plasma cholesterol and an increase in liver cholesterol. The fecal excr...

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Veröffentlicht in:	Journal of steroid biochemistry 1978-08, Vol.9 (8), p.775-778
1. Verfasser:	Subbiah, M.T.Ravi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Body Weight Cholesterol - metabolism Feces - chemistry Female Liver - drug effects Liver - metabolism Orotic Acid - metabolism Orotic Acid - pharmacology Rats Sterols - metabolism
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Zusammenfassung:	The early effects of orotic add on the concentration of plasma cholesterol, liver cholesterol, and fecal excretion of neutral sterols and bile acids were examined. Feeding rats 1% orotic acid for a week resulted in a decrease in plasma cholesterol and an increase in liver cholesterol. The fecal excretion of bile adds and neutral sterols was decreased significantly ( P < 0.02). This decreased the total sterol excretion ( P < 0.01). In the bile there was a decrease in the concentration of chenodeoxycholic acid while an increase was observed in the concentration of β-muricholic acid.
ISSN:	0022-4731
DOI:	10.1016/0022-4731(78)90199-1