The effect of cannabinoids ( Δ9-THC and Δ8-THC) on hepatic microsomal metabolism of testosterone in vitro

The effects of Δ 9-THC and Δ 8-THC on testosterone metabolism by rat liver microsomal enzymes were studied in vitro. Δ 9-THC (25 μM) inhibit the 5α-reduction of testosterone while Δ 8-THC has no effect at double the concentration. Both Δ 9-THC and Δ 8-THC inhibit the hydroxylation of testosterone. T...

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Veröffentlicht in:	Biochemical pharmacology 1978, Vol.27 (13), p.1725-1728
Hauptverfasser:	Chan, Mo Yin, Tse, Aida
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dronabinol - pharmacology Hydroxylation In Vitro Techniques Kinetics Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Oxidation-Reduction Rats Testosterone - metabolism
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Zusammenfassung:	The effects of Δ 9-THC and Δ 8-THC on testosterone metabolism by rat liver microsomal enzymes were studied in vitro. Δ 9-THC (25 μM) inhibit the 5α-reduction of testosterone while Δ 8-THC has no effect at double the concentration. Both Δ 9-THC and Δ 8-THC inhibit the hydroxylation of testosterone. This inhibition is dose dependent over the dose range (25–100 μM) tested. At the same molar concentration, Δ 8-THC inhibits testosterone hydroxylation to a greater extent than Δ 9-THC. The kinetic data suggest that the observed inhibition on 5α-reduction and total hydroxylation by the tetrahydrocannabinoids is of the competitive type.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(78)90547-6