3H-Imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium

The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently...

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Veröffentlicht in:	Psychopharmacology 1982-05, Vol.77 (1), p.94-97
Hauptverfasser:	Plenge, P, Mellerup, E T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - drug effects Brain - metabolism Female Imipramine - metabolism Imipramine - pharmacology Kinetics Lithium - pharmacology Membranes - metabolism Rats Rats, Inbred Strains
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