3H-Imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium

3H-Imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium

The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently...

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Veröffentlicht in:Psychopharmacology 1982-05, Vol.77 (1), p.94-97
Hauptverfasser: Plenge, P, Mellerup, E T
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Binding Sites - drug effects
Brain - metabolism
Female
Imipramine - metabolism
Imipramine - pharmacology
Kinetics
Lithium - pharmacology
Membranes - metabolism
Rats
Rats, Inbred Strains
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Zusammenfassung:The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.
ISSN:0033-3158
1432-2072
DOI:10.1007/bf00436105