Possible link between changes in plasma 24,25-dihydroxyvitamin D and healing of bone resorption in dialysis osteodystrophy
Histomorphometric studies of bone biopsies were performed on 12 hemodialyzed patients before and after six months of treatment with 25-(OH) and 1α-(OH) vitamin D 3. Patients could be classified into three groups according to bone resorption: Group I with normal bone resorption; Group II with elevate...
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Veröffentlicht in: | Metabolic bone disease & related research 1982, Vol.4 (1), p.25-30 |
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Zusammenfassung: | Histomorphometric studies of bone biopsies were performed on 12 hemodialyzed patients before and after six months of treatment with 25-(OH) and 1α-(OH) vitamin D
3. Patients could be classified into three groups according to bone resorption: Group I with normal bone resorption; Group II with elevated initial bone resorption unresponsive to vitamin D treatment; group III with elevated initial bone resorption sensitive to vitamin D treatment. None of the patients had histological signs of osteomalacia. In Group I, plasma concentrations of 24,25-(OH)
2D and the ratio of 24,25-(OH)
2D to 25-(OH) D remained in the normal range throughout the study; in Group II these parameters were subnormal initially and did not increase above normal except in one case; in Group III, plasma concentrations of 24,25-(OH)
2D were high before or at the beginning of vitamin D administration and normal at the time of the second biopsy and wide variations were observed in the ratio of 24,25(OH)
2D to 25-(OH)D. No difference was found between these last two groups with regard to the cumulative dose of vitamin D derivatives administered or the changes in plasma PTH, CT, calcium and phosphate. These observations suggest a specific regulation of plasma 24,25(OH)
2D concentrations in hemodialyzed patients and a possible link (independent of circulating PTH, CT, or phosphate) between this regulation and healing of bone resorption. However, no correlation was found between plasma 24,25-(OH)
2D and either one of the simultaneously measured biochemical or histological parameters.
Une étude histomorphométrique de la biopsie osseuse a été réalisée chez 12 malades en hémodialyse avant et aprés six mois de traitement par la 25-(OH) et la 1 alpha OH vitamine D3. Ces malades avaient été classés en 3 groupes suivant leur résorption osseuse: Groups I avec résorption normale; groups II avec résorption initials élevée ne répondant pas au traitement par la vitamine D; groups III avec résorption initiate élevée mais répondant à la vitamine D. Aucun des malades n'avait de signes histologiques d'ostéomalacie. Dans le groupe I, les concentrations plasmatiques du 24,25-(OH)
2D et le rapport de la concentration du 24,25-(OH)
2D sur celle du 25-(OH) D resta dans les valeurs normales tout au long de l'étude. Dans le groups II, paramètres étaient initialement inférieurs á la normale et n'augmentèrent pas, sauf dans un cas. Dans le groupe III, les concentrations plasmatiques du 24,25-(OH)
2D étaient é1evées avant |
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ISSN: | 0221-8747 1878-061X |
DOI: | 10.1016/0221-8747(82)90005-4 |