Serotonin as a neurotransmitter in cerebral arteries
Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries containe...
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| Veröffentlicht in: | Brain research 1982-09, Vol.247 (2), p.388-392 |
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| container_end_page | 392 |
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| container_title | Brain research |
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| creator | Griffith, S.G. Lincoln, J. Burnstock, G. |
| description | Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries contained high levels of 5-HT (over 0.5 μg/g wet weight) and its metabolite, 5-hydroxyindoleacetic acid (over 0.6 μg/g wet weight); and a 5-HT-immunoreactive nerve plexus was demonstrated. The possible role of these nerves is discussed. |
| doi_str_mv | 10.1016/0006-8993(82)91266-5 |
| format | Article |
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The possible role of these nerves is discussed.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(82)91266-5</identifier><identifier>PMID: 6127149</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>5-hydroxytryptamine ; Animals ; cerebral blood vessels ; Dopamine - pharmacology ; Electric Stimulation ; Histamine - pharmacology ; In Vitro Techniques ; Male ; migraine ; Neurotransmitter Agents ; non-adrenergic, non-cholinergic nerves ; Norepinephrine - pharmacology ; perivascular nerves ; rabbit vertebral artery ; Rabbits ; Serotonin - pharmacology ; Serotonin - physiology ; serotoninergic nerves ; Synaptic Transmission ; Vasoconstriction ; Vertebral Artery - innervation</subject><ispartof>Brain research, 1982-09, Vol.247 (2), p.388-392</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-5c6782025cc8da8dc953a0ab1f3bf19b09f910dda9490650590f484afcb210783</citedby><cites>FETCH-LOGICAL-c388t-5c6782025cc8da8dc953a0ab1f3bf19b09f910dda9490650590f484afcb210783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(82)91266-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6127149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griffith, S.G.</creatorcontrib><creatorcontrib>Lincoln, J.</creatorcontrib><creatorcontrib>Burnstock, G.</creatorcontrib><title>Serotonin as a neurotransmitter in cerebral arteries</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries contained high levels of 5-HT (over 0.5 μg/g wet weight) and its metabolite, 5-hydroxyindoleacetic acid (over 0.6 μg/g wet weight); and a 5-HT-immunoreactive nerve plexus was demonstrated. The possible role of these nerves is discussed.</description><subject>5-hydroxytryptamine</subject><subject>Animals</subject><subject>cerebral blood vessels</subject><subject>Dopamine - pharmacology</subject><subject>Electric Stimulation</subject><subject>Histamine - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>migraine</subject><subject>Neurotransmitter Agents</subject><subject>non-adrenergic, non-cholinergic nerves</subject><subject>Norepinephrine - pharmacology</subject><subject>perivascular nerves</subject><subject>rabbit vertebral artery</subject><subject>Rabbits</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin - physiology</subject><subject>serotoninergic nerves</subject><subject>Synaptic Transmission</subject><subject>Vasoconstriction</subject><subject>Vertebral Artery - innervation</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMo67r6Hyj0JHqoTj6bXARZ_IIFD-o5pOkUIt12TVrB_97WXTzqaXjz3ryBHyGnFK4oUHUNACrXxvALzS4NZUrlco_MqS5YrpiAfTL_jRySo5TeR8m5gRmZKcoKKsyciBeMXd-1oc1cylzW4jDq6Nq0Dn2PMRsNjxHL6JrMxXETMB2Tg9o1CU92c0He7u9el4_56vnhaXm7yj3Xus-lV4VmwKT3unK68kZyB66kNS9rakowtaFQVc4IA0qCNFALLVztS0ah0HxBzre9m9h9DJh6uw7JY9O4Frsh2UIwZoDTf4NUSg5CTY1iG_SxSylibTcxrF38shTsRNVOyOyEzGpmf6haOZ6d7fqHco3V79EO4-jfbH0caXwGjDb5gK3HKkT0va268PeDbzA-hUA</recordid><startdate>19820916</startdate><enddate>19820916</enddate><creator>Griffith, S.G.</creator><creator>Lincoln, J.</creator><creator>Burnstock, G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19820916</creationdate><title>Serotonin as a neurotransmitter in cerebral arteries</title><author>Griffith, S.G. ; Lincoln, J. ; Burnstock, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-5c6782025cc8da8dc953a0ab1f3bf19b09f910dda9490650590f484afcb210783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>5-hydroxytryptamine</topic><topic>Animals</topic><topic>cerebral blood vessels</topic><topic>Dopamine - pharmacology</topic><topic>Electric Stimulation</topic><topic>Histamine - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>migraine</topic><topic>Neurotransmitter Agents</topic><topic>non-adrenergic, non-cholinergic nerves</topic><topic>Norepinephrine - pharmacology</topic><topic>perivascular nerves</topic><topic>rabbit vertebral artery</topic><topic>Rabbits</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin - physiology</topic><topic>serotoninergic nerves</topic><topic>Synaptic Transmission</topic><topic>Vasoconstriction</topic><topic>Vertebral Artery - innervation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griffith, S.G.</creatorcontrib><creatorcontrib>Lincoln, J.</creatorcontrib><creatorcontrib>Burnstock, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griffith, S.G.</au><au>Lincoln, J.</au><au>Burnstock, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin as a neurotransmitter in cerebral arteries</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1982-09-16</date><risdate>1982</risdate><volume>247</volume><issue>2</issue><spage>388</spage><epage>392</epage><pages>388-392</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries contained high levels of 5-HT (over 0.5 μg/g wet weight) and its metabolite, 5-hydroxyindoleacetic acid (over 0.6 μg/g wet weight); and a 5-HT-immunoreactive nerve plexus was demonstrated. The possible role of these nerves is discussed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6127149</pmid><doi>10.1016/0006-8993(82)91266-5</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1982-09, Vol.247 (2), p.388-392 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74229031 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 5-hydroxytryptamine Animals cerebral blood vessels Dopamine - pharmacology Electric Stimulation Histamine - pharmacology In Vitro Techniques Male migraine Neurotransmitter Agents non-adrenergic, non-cholinergic nerves Norepinephrine - pharmacology perivascular nerves rabbit vertebral artery Rabbits Serotonin - pharmacology Serotonin - physiology serotoninergic nerves Synaptic Transmission Vasoconstriction Vertebral Artery - innervation |
| title | Serotonin as a neurotransmitter in cerebral arteries |
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