Serotonin as a neurotransmitter in cerebral arteries

Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries containe...

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Veröffentlicht in:	Brain research 1982-09, Vol.247 (2), p.388-392
Hauptverfasser:	Griffith, S.G., Lincoln, J., Burnstock, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptamine Animals cerebral blood vessels Dopamine - pharmacology Electric Stimulation Histamine - pharmacology In Vitro Techniques Male migraine Neurotransmitter Agents non-adrenergic, non-cholinergic nerves Norepinephrine - pharmacology perivascular nerves rabbit vertebral artery Rabbits Serotonin - pharmacology Serotonin - physiology serotoninergic nerves Synaptic Transmission Vasoconstriction Vertebral Artery - innervation
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Beschreibung
Zusammenfassung:	Evidence is presented for the existence of serotoninergic nerves in rabbit verterbral artery: the neurogenic vasoconstrictor response in isolated vessels was resistant to adrenoceptor and cholinoceptor blockede but was blocked by ketanserin, a serotonin (5-HT) antagonist; vertebral arteries contained high levels of 5-HT (over 0.5 μg/g wet weight) and its metabolite, 5-hydroxyindoleacetic acid (over 0.6 μg/g wet weight); and a 5-HT-immunoreactive nerve plexus was demonstrated. The possible role of these nerves is discussed.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(82)91266-5