Microaggregate formation in whole blood exposed to shear stress

Microaggregate formation in whole blood exposed to shear stress

Microaggregate size distributions were measured in fresh blood sheared in a rotational viscometer at 37°. The number, N A, and the total volume, V A, of aggregate particles 13–101 μm in diameter increased with shear stress at exposures of 0–300 dynes/cm 2 for 5 min. The mean size per aggregate, V A...

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Veröffentlicht in:Microvascular research 1978-09, Vol.16 (2), p.263-271
Hauptverfasser: Dewitz, T.S., Martin, R.R., Solis, R.T., Hellums, J.D., McIntire, L.V.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Diphosphate - pharmacology
Blood Platelets
Humans
Leukocytes - physiology
Platelet Aggregation - drug effects
Stress, Mechanical
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Zusammenfassung:Microaggregate size distributions were measured in fresh blood sheared in a rotational viscometer at 37°. The number, N A, and the total volume, V A, of aggregate particles 13–101 μm in diameter increased with shear stress at exposures of 0–300 dynes/cm 2 for 5 min. The mean size per aggregate, V A N A , decreased with shear stress so that V A also decreased at shear stresses greater than 450 dynes/cm 2 maintained for 10 min. Aggregability to 0.2–2.0 μ M ADP was progressively inhibited after exposure to increasing shear stress. The volume of platelet microaggregates may be increased substantially by the involvement of leukocytes.
ISSN:0026-2862
1095-9319
DOI:10.1016/0026-2862(78)90059-6