Theorems on the Apparent Volume of Distribution of a Linear System

If the concentration of drug in one compartment of a linear N-compartrnent system, without sinks and loss only from the sampled compartment is sampled, then the total apparent volume of distribution can be determined without knowledge of the topology of the system. This apparent volume is identical...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1982-07, Vol.71 (7), p.793-795
1. Verfasser:	Vaughan, D.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Linear system-theorems on the apparent volume of distribution Mathematics Models, Biological Pharmaceutical Preparations - metabolism theorems of a linear system Theorems-apparent volume of distribution of a linear system Volume of distribution-apparent Volume of distribution—apparent, theorems of a linear system
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Zusammenfassung:	If the concentration of drug in one compartment of a linear N-compartrnent system, without sinks and loss only from the sampled compartment is sampled, then the total apparent volume of distribution can be determined without knowledge of the topology of the system. This apparent volume is identical to the apparent volume of the corresponding closed system.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600710718