Abnormal Left Ventricular Function in Hyperthyroidism: Evidence for a Possible Reversible Cardiomyopathy

Abnormal Left Ventricular Function in Hyperthyroidism: Evidence for a Possible Reversible Cardiomyopathy

We assessed the effects of exercise and beta-adrenoceptor blockade on left ventricular ejection fraction (LVEF) measured by radionuclide ventriculography in nine patients with uncomplicated hyperthyroidism. Patients were studied in both the hyperthyroid and euthyroid states. The hyperthyroid state w...

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Veröffentlicht in:The New England journal of medicine 1982-11, Vol.307 (19), p.1165-1170
Hauptverfasser: Forfar, John Colin, Muir, Alexander Laird, Sawers, Stewart Allison, Toft, Anthony Douglas
Format: Artikel
Sprache:eng
Schlagworte:
Adrenergic receptors
Adult
Blood Pressure
Cardiac Output
Cardiology
Cardiomyopathies - etiology
Cardiomyopathy
Female
Heart - physiopathology
Heart failure
Heart Rate
Heart Ventricles - diagnostic imaging
Humans
Hyperthyroidism
Hyperthyroidism - complications
Hyperthyroidism - physiopathology
Male
Middle Aged
Patients
Physical Exertion
Physical training
Plasma
Propranolol
Propranolol - pharmacology
Radionuclide Imaging
Space life sciences
Stroke Volume
Thyroid diseases
Thyroid hormones
Ventricle
Workloads
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Zusammenfassung:We assessed the effects of exercise and beta-adrenoceptor blockade on left ventricular ejection fraction (LVEF) measured by radionuclide ventriculography in nine patients with uncomplicated hyperthyroidism. Patients were studied in both the hyperthyroid and euthyroid states. The hyperthyroid state was characterized by a high LVEF at rest but — paradoxically — by a significant fall (P
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198211043071901