STUDIES OF THE CONCENTRATION OF CEFOXITIN IN ORO-MAXILLARY TISSUES AND SERUM

STUDIES OF THE CONCENTRATION OF CEFOXITIN IN ORO-MAXILLARY TISSUES AND SERUM

We studied cefoxitin (CFX) concentration of oro-maxillary tissues in rats and in18patients by means of bioassay method.In rats, the highest peak concentrations were observed in the gingiva and buccal mucosa followed by the tongue, submaxillary gland, lower jaw bone and the masseter muscle in the ord...

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Veröffentlicht in:Japanese journal of antibiotics 1982/03/25, Vol.35(3), pp.845-849
Hauptverfasser: SAITO, KENICHI, FUJII, KENICHI, AOKI, SHINICHIRO, MICHI, KENICHI, UENO, TADASHI, HASHIMOTO, KENJI, IWAKI, HIROSHI, SHIMIZU, MASATSUGU, SHIODA, SHIGETOSHI
Format: Artikel
Sprache:jpn
Schlagworte:
Adult
Aged
Animals
Cefoxitin - administration & dosage
Cefoxitin - blood
Cefoxitin - metabolism
Female
Humans
Infusions, Parenteral
Injections, Subcutaneous
Male
Maxilla - metabolism
Middle Aged
Mouth - metabolism
Rats
Rats, Inbred Strains
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Zusammenfassung:We studied cefoxitin (CFX) concentration of oro-maxillary tissues in rats and in18patients by means of bioassay method.In rats, the highest peak concentrations were observed in the gingiva and buccal mucosa followed by the tongue, submaxillary gland, lower jaw bone and the masseter muscle in the order listed. In patients, the highest peak concentrations were observed in the maxillary sinus mucosa and peak concentrations in oro-maxillary tissues were froml/5to2/3of the corresponding serum concentrations. Further study is needed to elucidate the reason for the high peak CFX concentration in the maxillary sinus mucosa and the apparent delayed peak concentration in the salivary gland.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.35.845