Factors that Influence the Efficacy of Topical Gentamicin Prophylaxis for Experimental Pseudomonas Keratitis

Factors that Influence the Efficacy of Topical Gentamicin Prophylaxis for Experimental Pseudomonas Keratitis

We evaluated the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis in rabbits by applying gentamicin in concentrations of 0.3 and 4 mg/100 ml, in both solution and ointment vehicles, one or four hours after a superficial stromal scratch was infected topically with Pse...

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Veröffentlicht in:American journal of ophthalmology 1982-08, Vol.94 (2), p.216-219
Hauptverfasser: Nassif, Kamal F., Davis, Starkey D., Hyndiuk, Robert A., Sarff, Larrie D., Divine, Kathy S.
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Topical
Animals
Gentamicins - administration & dosage
Keratitis - prevention & control
Male
Ointments
Pseudomonas
Pseudomonas Infections - prevention & control
Rabbits
Solutions
Time Factors
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Zusammenfassung:We evaluated the efficacy of topical gentamicin prophylaxis for experimental Pseudomonas keratitis in rabbits by applying gentamicin in concentrations of 0.3 and 4 mg/100 ml, in both solution and ointment vehicles, one or four hours after a superficial stromal scratch was infected topically with Pseudomonas organisms. Under these conditions the most effective prophylaxis was that given early, in solution, and in high concentration
ISSN:0002-9394
1879-1891
DOI:10.1016/0002-9394(82)90078-2