Isolation and Characterization of Palystatins A-D

Isolation and Characterization of Palystatins A-D

Four new and relatively low molecular weight (approximately 3,000-5,000), cell growth (PS) inhibitory peptides designated palystatins A-D have been isolated from the Indian Ocean Palythao liscia Haddon and Duerden. The Isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100)...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 1982-05, Vol.45 (3), p.272-276
Hauptverfasser: Pettit, George R, Fujii, Youichi, Hasler, Julia A, Schmidt, Jean M
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids - analysis
Animals
Antineoplastic Agents - isolation & purification
Cnidaria - analysis
Glycopeptides - isolation & purification
Mice
Molecular Weight
Neoplasms, Experimental - drug therapy
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Zusammenfassung:Four new and relatively low molecular weight (approximately 3,000-5,000), cell growth (PS) inhibitory peptides designated palystatins A-D have been isolated from the Indian Ocean Palythao liscia Haddon and Duerden. The Isolation utilized chromatographic procedures (Amberlite XAD-7 to Sephadex G-100) guided by bioassay with the P388 murine lymphocytic leukemia (PS system). Palystatins A-D exhibited PS cytotoxicity in the range ED50 0.02-0.0023 microgram/ml.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50021a007