Inhibition of [3H]Diazepam and [3H]3‐Carboethoxy‐β‐Carboline Binding by Irazepine: Evidence for Multiple “Domains” of the Benzodiazepine Receptor

Inhibition of [3H]Diazepam and [3H]3‐Carboethoxy‐β‐Carboline Binding by Irazepine: Evidence for Multiple “Domains” of the Benzodiazepine Receptor

: The binding of [3H]diazepam and [3H]3‐carboethoxy‐β‐carboline was examined in rat brain synaptosomal membranes treated with irazepine, an alkylating benzodiazepine. Under incubation conditions that resulted in a 25–33% reduction in the Bmax of [3H]diazepam binding, only modest (

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Veröffentlicht in:Journal of neurochemistry 1982-10, Vol.39 (4), p.1142-1146
Hauptverfasser: Skolnick, Phil, Schweri, Margaret, Kutter, Eberhard, Williams, Evan, Paul, Steven
Format: Artikel
Sprache:eng
Schlagworte:
3‐Carboethoxy
Animals
Benzodiazepine receptor
Benzodiazepinones - pharmacology
Carbolines - metabolism
Diazepam
Diazepam - metabolism
Domain
Indoles - metabolism
Irazepine
Macromolecular Substances
Male
Molecular Weight
Rats
Rats, Inbred Strains
Receptors, Drug - drug effects
Receptors, GABA-A
β‐carboline
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Zusammenfassung:: The binding of [3H]diazepam and [3H]3‐carboethoxy‐β‐carboline was examined in rat brain synaptosomal membranes treated with irazepine, an alkylating benzodiazepine. Under incubation conditions that resulted in a 25–33% reduction in the Bmax of [3H]diazepam binding, only modest (
ISSN:0022-3042
1471-4159
DOI:10.1111/j.1471-4159.1982.tb11507.x