Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species

Intravenous injection of lysophosphatidic acid was found to cause hypertension in rats and guinea pigs, but hypotension in cats and rabbits. The potencies of the pressor and depressor effects of synthetic lysophosphatidic acids in rats and cats depended on their chain length and the degree of unsatu...

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Veröffentlicht in:	Lipids 1978-08, Vol.13 (8), p.572-574
Hauptverfasser:	Tokumura, A, Fukuzawa, K, Tsukatani, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Cats Dose-Response Relationship, Drug Fatty Acids, Unsaturated - pharmacology Guinea Pigs human nutrition Lysophosphatidylcholines nutrition education Phosphatidic Acids - administration & dosage Phosphatidic Acids - chemical synthesis Phosphatidic Acids - pharmacology Rabbits Rats Species Specificity
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Beschreibung
Zusammenfassung:	Intravenous injection of lysophosphatidic acid was found to cause hypertension in rats and guinea pigs, but hypotension in cats and rabbits. The potencies of the pressor and depressor effects of synthetic lysophosphatidic acids in rats and cats depended on their chain length and the degree of unsaturation of their fatty acyl moieties.
ISSN:	0024-4201 1558-9307
DOI:	10.1007/BF02533598