Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats

Selective reduction of one class of dopamine receptor binding sites in the corpus striatum of aged rats

In aged rats (21–23 vs 3 month) the neuroleptic receptor number was reduced in the striatum (−53%), in the limbic area (−36%), and not changed in the cortex. The in vitro pharmacological profile of the remaining [ 3H]spiroperidol receptors in each area was not modified in aged animals. The binding o...

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Veröffentlicht in:Brain research 1982-06, Vol.242 (2), p.361-364
Hauptverfasser: De Blasi, Antonio, Mennini, Tiziana
Format: Artikel
Sprache:eng
Schlagworte:
[ 3H]spiroperidol binding
Aging
Animals
Binding, Competitive
Brain - growth & development
Brain - metabolism
Cell Membrane - metabolism
Corpus Striatum - growth & development
Corpus Striatum - metabolism
cortex
dopamine
dopamine receptors
Fluorescent Dyes - metabolism
Kinetics
limbic system
Male
Rats
Rats, Inbred Strains
Receptors, Dopamine - metabolism
Serotonin - metabolism
serotonin receptors
spiperone
Spiperone - metabolism
striate cortex
Tetrahydronaphthalenes - metabolism
Tissue Distribution
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Zusammenfassung:In aged rats (21–23 vs 3 month) the neuroleptic receptor number was reduced in the striatum (−53%), in the limbic area (−36%), and not changed in the cortex. The in vitro pharmacological profile of the remaining [ 3H]spiroperidol receptors in each area was not modified in aged animals. The binding of [ 3H]ADTN (2-amino-6, 7-dihydroxy-1,2,3,4-tetrahydronapthalene) in the striatum and of [ 3H]serotonin ([ 3H-5 HT) in the cortex was also the same in both age groups.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(82)90325-0