Lipid environment of acetylcholine receptor from Torpedo californica

Lipid environment of acetylcholine receptor from Torpedo californica

The lipid matrix of both acetylcholine receptor (AcChR)-rich and AcChR-poor membranes from Torpedo californica electroplax has been chemically characterized. AcChR-rich membranes contained higher levels of free cholesterol and slightly higher proportions of polyunsaturated ethanolamine phosphoglycer...

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Veröffentlicht in:Biochemistry (Easton) 1982-07, Vol.21 (14), p.3467-3474
Hauptverfasser: Gonzalez-Ros, J. M, Llanillo, M, Paraschos, A, Martinez-Carrion, M
Format: Artikel
Sprache:eng
Schlagworte:
acetylcholine
Animals
Centrifugation, Density Gradient
Diphenylhexatriene
Electric Organ - analysis
Fatty Acids - analysis
lipid composition
lipids
Marine
Membrane Lipids - analysis
neurotransmitters
Optical Rotation
Receptors, Cholinergic - analysis
Spectrometry, Fluorescence
Temperature
Torpedo
Torpedo californica
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Zusammenfassung:The lipid matrix of both acetylcholine receptor (AcChR)-rich and AcChR-poor membranes from Torpedo californica electroplax has been chemically characterized. AcChR-rich membranes contained higher levels of free cholesterol and slightly higher proportions of polyunsaturated ethanolamine phosphoglycerides. Major fatty acid components in the total lipid extracts from either membrane fraction were 24% palmitic, 20% docosahexaenoic, and 20% oleic acids.
ISSN:0006-2960
1520-4995
DOI:10.1021/bi00257a033