Type II Collagen Autoimmunity in Otosclerosis and Meniere's Disease

Type II Collagen Autoimmunity in Otosclerosis and Meniere's Disease

Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies t...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1982-09, Vol.217 (4565), p.1153-1155
Hauptverfasser: Yoo, T. J., Stuart, J. M., Kang, A. H., Townes, A. S., Tomoda, K., Dixit, S.
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Autoantibodies - analysis
Autoimmune Diseases - immunology
Autoimmunity
Collagen - classification
Collagen - immunology
Collagens
Delta cells
Hormones
Humans
Infections
Insulin
Islet cells
Meniere Disease - immunology
Menieres disease
Osteosclerosis - immunology
Otosclerosis
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Zusammenfassung:Antibodies to collagen types I, II, and IV were measured in patients with otosclerosis and patients with Meniere's disease. Levels of antibodies to type II collagen were significantly higher in these patients than in control subjects, while no differences were found among levels of antibodies to collagen type I or type IV. These observations suggest a possible role for type II collagen autoimmunity in the etiology of otosclerosis and Meniere's disease.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7112122