Intervening effect of L-ascorbic acid on Epstein-Barr virus activation in human lymphoblastoid cells and its comparison with the effect of retinoic acid

L-Ascorbic acid was found to reduce the induction of Epstein-Barr virus-associated antigens in human lymphoblastoid P3HR-1 cells and Raji cells to the level of approximately 45–85% of the untreated control culture at concentrations of 100–1000 μM. When such an effect of L-ascorbic acid was compared...

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Veröffentlicht in:	Cancer letters 1982-03, Vol.15 (3), p.255-259
Hauptverfasser:	Morigaki, Tadaaki, Ito, Yohei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Viral Ascorbic Acid - pharmacology Cells, Cultured Herpesvirus 4, Human - drug effects Humans Lymphocytes Tretinoin - pharmacology
Online-Zugang:	Volltext
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Zusammenfassung:	L-Ascorbic acid was found to reduce the induction of Epstein-Barr virus-associated antigens in human lymphoblastoid P3HR-1 cells and Raji cells to the level of approximately 45–85% of the untreated control culture at concentrations of 100–1000 μM. When such an effect of L-ascorbic acid was compared with the inhibitory effect of retinoic acid known to occur in the same system, the intervention was weaker but its cytotoxicity was remarkably lower than the latter compound.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/0304-3835(82)90126-4