Influence of histamine and pentobarbitone on plasma and CSF vasopressin levels of hypophysectomized rats

Histamine increased vasopressin levels, as measured by radioimmunoassay (RIA), in both cerebrospinal fluid (CSF) and plasma of hypophysectomized rats, while histamine enhanced plasma but not CSF levels of vasopressin in sham operated rats. Pentobarbitone increased CSF vasopressin levels in hypophyse...

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Veröffentlicht in:	Brain research bulletin 1982-05, Vol.8 (5), p.555-557
Hauptverfasser:	Mens, Wim B.J., Van Dam, Anja F., Van Wimersma Greidanus, Tjeerd B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - metabolism Blood Cerebrospinal fluid Histamine Histamine - pharmacology Hypophysectomy Male Nerve Regeneration Pentobarbital - pharmacology Pentobarbitone Pituitary Gland - physiology Pituitary Gland, Posterior - physiology Radioimmunoassay Rats Rats, Inbred Strains Vasopressin
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Beschreibung
Zusammenfassung:	Histamine increased vasopressin levels, as measured by radioimmunoassay (RIA), in both cerebrospinal fluid (CSF) and plasma of hypophysectomized rats, while histamine enhanced plasma but not CSF levels of vasopressin in sham operated rats. Pentobarbitone increased CSF vasopressin levels in hypophysectomized rats and in sham operated animals. The present data demonstrate that the histamine induced elevation of vasopressin levels in the blood is only temporarily disturbed after hypophysectomy, while the effect of histamine on CSF vasopressin levels of hypophysectomized rats is of a more permanent nature.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/0361-9230(82)90016-8