Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1982-09, Vol.217 (4566), p.1247-1249
1. Verfasser: Klotz, Irving M.
Format: Artikel
Sprache:eng
Schlagworte:
Atoms
Climate models
Clouds
Inflection points
Insulin
Ions
Kinetics
Ligands
Ligands - metabolism
Line graphs
Molecules
Receptors
Receptors, Cell Surface - metabolism
Statistics as Topic - methods
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container_title Science (American Association for the Advancement of Science)
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creator Klotz, Irving M.
description Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.
doi_str_mv 10.1126/science.6287580
format Article
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source MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science
subjects Atoms
Climate models
Clouds
Inflection points
Insulin
Ions
Kinetics
Ligands
Ligands - metabolism
Line graphs
Molecules
Receptors
Receptors, Cell Surface - metabolism
Statistics as Topic - methods
title Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies
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