Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Science (American Association for the Advancement of Science) 1982-09, Vol.217 (4566), p.1247-1249
1. Verfasser: Klotz, Irving M.
Format: Artikel
Sprache:eng
Schlagworte:
Atoms
Climate models
Clouds
Inflection points
Insulin
Ions
Kinetics
Ligands
Ligands - metabolism
Line graphs
Molecules
Receptors
Receptors, Cell Surface - metabolism
Statistics as Topic - methods
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Data for ligand and receptor binding presented in the format of a Scatchard graph are compared with the same data shown as bound ligand plotted against the logarithm of free ligand. From this comparison it is apparent that extrapolations in the Scatchard graph to yield total number of receptor sites are generally not correct.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6287580