TRANSPORTATION OF CEFOTIAM FROM SERUM TO CEREBROSPINAL FLUID

Cefotiam (1g) was administered by one-shot intravenous injection to the patients proceeding a brain surgery. The cerebrospinal fluid (CSF) and serum were taken as a specimen, and the concentration CTM was assayed by agar-well method using Proteus mirabilis ATCC 21100. The most high concentration of CTM was 2,273 μg/ml in serum, and 2.3 μg/ml in CSF, respectively. The concentration of CTM in serum, CSF, and CSF/serum ratio were determined at the indicated time. It appears likely that CTM can pass into CSF more easily than other cephalosporins.