CARDIOVASCULAR EFFECTS OF ISOPROTERENOL AND POSSIBLE ANTAGONISTIC ACTIONS OF PROPRANOLOL AND PERHEXILINE

A beta-adrenergic blocking activity of perhexiline was compared with that of propranolol. In the Langendorff's preparation of rabbits, canine heart-lung preparation, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular f...

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Veröffentlicht in:	JAPANESE CIRCULATION JOURNAL 1978/05/20, Vol.42(4), pp.425-432
Hauptverfasser:	MATSUKAWA, HIDEHIKO, OKABE, EIICHIRO, SAKAMOTO, HARUHIKO, CHO, YOUNG W., ITO, HARUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Antagonistic action Blood Pressure - drug effects Cardiac Output - drug effects Dogs Female Heart Rate - drug effects Hemodynamics - drug effects In Vitro Techniques Isoproterenol Isoproterenol - antagonists & inhibitors Male Myocardial Contraction - drug effects Perhexiline Perhexiline - pharmacology Piperidines - pharmacology Propranolol Propranolol - pharmacology Rabbits
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Zusammenfassung:	A beta-adrenergic blocking activity of perhexiline was compared with that of propranolol. In the Langendorff's preparation of rabbits, canine heart-lung preparation, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effectively blocked by propranolol. These data suggest that perhexiline is not a beta-adrenergic receptor blocking agent.
ISSN:	0047-1828 1347-4839
DOI:	10.1253/jcj.42.425