Antacid properties of a sodium citrate preparation
A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,...
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Veröffentlicht in: | South African medical journal 1978-07, Vol.54 (3), p.105-107 |
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description | A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,0 in a significant number of subjects. Similar results were obtained with both single doses (4 and 12 g) after 3 - 6 days of continuous therapy at the appropriate dose given every 6 hours. It is concluded that the urine-alkalinizing sodium citrate preparation reduced intragastric acidity significantly. |
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When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,0 in a significant number of subjects. Similar results were obtained with both single doses (4 and 12 g) after 3 - 6 days of continuous therapy at the appropriate dose given every 6 hours. 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When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,0 in a significant number of subjects. Similar results were obtained with both single doses (4 and 12 g) after 3 - 6 days of continuous therapy at the appropriate dose given every 6 hours. It is concluded that the urine-alkalinizing sodium citrate preparation reduced intragastric acidity significantly.</description><subject>Adult</subject><subject>Antacid properties</subject><subject>Antacids</subject><subject>Blood</subject><subject>Citrates - pharmacology</subject><subject>Clinical Trials as Topic</subject><subject>Gastric acid output</subject><subject>Gastric Juice - secretion</subject><subject>Gastric pH</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Pharmacology</subject><subject>Sodium citrate</subject><subject>Urine</subject><issn>0256-9574</issn><issn>2078-5135</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkDtPAzEQhC1EBEfgF9BcRWfJb5_LU8QjKBIN1Jbt20hG9-LsK_j3OCTV7ugbrXbmClWM6AZLyuU1qgiTChupxS26S-mbFC2NukEbZrjQFWLtmF2IXT0v0wxLjpDq6Vi7Ok1dXIc6xLy4DAXD7MoWp_EebY6uT_BwmVv09fL8uXvDh4_X_a494JkJlrFXzmsPQYtAKDDRSKYENdQF7RVrlPSmk1R6bxQ1HnwRijMZeKcbxZTiW_R0vlte-1khZTvEFKDv3QjTmqwWVHOiZDE-XoyrH6Cz8xIHt_za_4iF4jNNzscRsk0OitFSIhmx7Xt7quvUlqWN4YT_AYxKWfA</recordid><startdate>19780715</startdate><enddate>19780715</enddate><creator>Moshal, M.G. & Naicker, M.</creator><general>Health and Medical Publishing Group (HMPG)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19780715</creationdate><title>Antacid properties of a sodium citrate preparation</title><author>Moshal, M.G. & Naicker, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p242t-b6ab7bec74c01e2485264191ac7b62865b9d515bb9619bebd516325c3d7862663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adult</topic><topic>Antacid properties</topic><topic>Antacids</topic><topic>Blood</topic><topic>Citrates - pharmacology</topic><topic>Clinical Trials as Topic</topic><topic>Gastric acid output</topic><topic>Gastric Juice - secretion</topic><topic>Gastric pH</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Pharmacology</topic><topic>Sodium citrate</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moshal, M.G. & Naicker, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>South African medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Moshal, M.G. & Naicker, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antacid properties of a sodium citrate preparation</atitle><jtitle>South African medical journal</jtitle><addtitle>S Afr Med J</addtitle><date>1978-07-15</date><risdate>1978</risdate><volume>54</volume><issue>3</issue><spage>105</spage><epage>107</epage><pages>105-107</pages><issn>0256-9574</issn><eissn>2078-5135</eissn><abstract>A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,0 in a significant number of subjects. Similar results were obtained with both single doses (4 and 12 g) after 3 - 6 days of continuous therapy at the appropriate dose given every 6 hours. It is concluded that the urine-alkalinizing sodium citrate preparation reduced intragastric acidity significantly.</abstract><cop>South Africa</cop><pub>Health and Medical Publishing Group (HMPG)</pub><pmid>29347</pmid><tpages>3</tpages></addata></record> |
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source | Sabinet Open Access Journals |
subjects | Adult Antacid properties Antacids Blood Citrates - pharmacology Clinical Trials as Topic Gastric acid output Gastric Juice - secretion Gastric pH Gastroenterology Humans Hydrogen-Ion Concentration Pharmacology Sodium citrate Urine |
title | Antacid properties of a sodium citrate preparation |
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