Antacid properties of a sodium citrate preparation

A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,...

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Veröffentlicht in:	South African medical journal 1978-07, Vol.54 (3), p.105-107
1. Verfasser:	Moshal, M.G. & Naicker, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antacid properties Antacids Blood Citrates - pharmacology Clinical Trials as Topic Gastric acid output Gastric Juice - secretion Gastric pH Gastroenterology Humans Hydrogen-Ion Concentration Pharmacology Sodium citrate Urine
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Zusammenfassung:	A sodium citrate preparation (Citro-Soda; Abbott) given in single doses of 4 or 12 g, satisfactorily increased the pH level of urine without affecting the systemic acid-base balance. When the sodium citrate preparation was administered in the 12-g single dose the gastric pH level was raised above 3,0 in a significant number of subjects. Similar results were obtained with both single doses (4 and 12 g) after 3 - 6 days of continuous therapy at the appropriate dose given every 6 hours. It is concluded that the urine-alkalinizing sodium citrate preparation reduced intragastric acidity significantly.
ISSN:	0256-9574 2078-5135