5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts
Normal and Rous sarcoma virus-infected chicken fibroblasts proliferate maximally in a culture medium containing a physiological (10 ng/ml) concentration of 5-methyltetrahydrofolic acid or folinic acid (5-formyltetrahydrofolic acid), while their maximal proliferation requires a hyperphysiological (10...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1978-11, Vol.38 (11 Pt 1), p.3966-3968 |
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| container_end_page | 3968 |
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| container_issue | 11 Pt 1 |
| container_start_page | 3966 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 38 |
| creator | Balk, S D LeStourgeon, D Mitchell, R S |
| description | Normal and Rous sarcoma virus-infected chicken fibroblasts proliferate maximally in a culture medium containing a physiological (10 ng/ml) concentration of 5-methyltetrahydrofolic acid or folinic acid (5-formyltetrahydrofolic acid), while their maximal proliferation requires a hyperphysiological (1000 ng/ml) concentration of folic acid. The normal and Rous-infected fibroblasts do not differ in their requirements for 5-methyltetrahydrofolate, folinic acid, or folic acid. |
| format | Article |
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The normal and Rous-infected fibroblasts do not differ in their requirements for 5-methyltetrahydrofolate, folinic acid, or folic acid.</description><subject>Animals</subject><subject>Avian Sarcoma Viruses</subject><subject>Cell Division - drug effects</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cells, Cultured</subject><subject>Chickens</subject><subject>Culture Media</subject><subject>Leucovorin - administration & dosage</subject><subject>Leucovorin - pharmacology</subject><subject>Tetrahydrofolates - administration & dosage</subject><subject>Tetrahydrofolates - pharmacology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLxDAUhbPwNY7-AxdZicIUkrRp2qUMvmBEEF2XPG5otG1mklSY_-MPtTqzcOHq3MP5OBzuAZoRQqqMF4KdoNMY3yfLKeHH6IhRRqtihr549gSp3XYJUpDt1gRvfec0ltqZBeaZ9aH_P8VXP_ewd9cLLAeD_8QBNqML0MOQIvYWD1OT7H6pFz9GHGXQvpf404UxZm6woBMYrFunP2DA1qngVSdjimfo0Mouwvle5-jt7vZ1-ZCtnu8flzerrGVFmTJdUSElE6XSZU6pqIwieV7ysqgMqyUxIJVWQikClhS15spQBlBVVltd1yqfo8td7zr4zQgxNb2LGrpODjAtbkRBS1FyMoEXe3BUPZhmHVwvw7bZfTX_BoPhdtg</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Balk, S D</creator><creator>LeStourgeon, D</creator><creator>Mitchell, R S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197811</creationdate><title>5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts</title><author>Balk, S D ; LeStourgeon, D ; Mitchell, R S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h246t-c817aa276bc631178db03365648d29a0deabcb7bb0ef049c5bd12ee88fcfc99b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Avian Sarcoma Viruses</topic><topic>Cell Division - drug effects</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cells, Cultured</topic><topic>Chickens</topic><topic>Culture Media</topic><topic>Leucovorin - administration & dosage</topic><topic>Leucovorin - pharmacology</topic><topic>Tetrahydrofolates - administration & dosage</topic><topic>Tetrahydrofolates - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balk, S D</creatorcontrib><creatorcontrib>LeStourgeon, D</creatorcontrib><creatorcontrib>Mitchell, R S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balk, S D</au><au>LeStourgeon, D</au><au>Mitchell, R S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1978-11</date><risdate>1978</risdate><volume>38</volume><issue>11 Pt 1</issue><spage>3966</spage><epage>3968</epage><pages>3966-3968</pages><issn>0008-5472</issn><abstract>Normal and Rous sarcoma virus-infected chicken fibroblasts proliferate maximally in a culture medium containing a physiological (10 ng/ml) concentration of 5-methyltetrahydrofolic acid or folinic acid (5-formyltetrahydrofolic acid), while their maximal proliferation requires a hyperphysiological (1000 ng/ml) concentration of folic acid. The normal and Rous-infected fibroblasts do not differ in their requirements for 5-methyltetrahydrofolate, folinic acid, or folic acid.</abstract><cop>United States</cop><pmid>212184</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 1978-11, Vol.38 (11 Pt 1), p.3966-3968 |
| issn | 0008-5472 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74167650 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Animals Avian Sarcoma Viruses Cell Division - drug effects Cell Transformation, Neoplastic Cells, Cultured Chickens Culture Media Leucovorin - administration & dosage Leucovorin - pharmacology Tetrahydrofolates - administration & dosage Tetrahydrofolates - pharmacology |
| title | 5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts |
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