5-Methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid (folinic acid), and folic acid requirements of normal and Rous sarcoma virus-infected chicken fibroblasts

Normal and Rous sarcoma virus-infected chicken fibroblasts proliferate maximally in a culture medium containing a physiological (10 ng/ml) concentration of 5-methyltetrahydrofolic acid or folinic acid (5-formyltetrahydrofolic acid), while their maximal proliferation requires a hyperphysiological (10...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1978-11, Vol.38 (11 Pt 1), p.3966-3968
Hauptverfasser:	Balk, S D, LeStourgeon, D, Mitchell, R S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Sarcoma Viruses Cell Division - drug effects Cell Transformation, Neoplastic Cells, Cultured Chickens Culture Media Leucovorin - administration & dosage Leucovorin - pharmacology Tetrahydrofolates - administration & dosage Tetrahydrofolates - pharmacology
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Zusammenfassung:	Normal and Rous sarcoma virus-infected chicken fibroblasts proliferate maximally in a culture medium containing a physiological (10 ng/ml) concentration of 5-methyltetrahydrofolic acid or folinic acid (5-formyltetrahydrofolic acid), while their maximal proliferation requires a hyperphysiological (1000 ng/ml) concentration of folic acid. The normal and Rous-infected fibroblasts do not differ in their requirements for 5-methyltetrahydrofolate, folinic acid, or folic acid.
ISSN:	0008-5472