Diabetic microangiopathy in KK mice: III. Effect of prolonged glyburide treatment on glomerulosclerosis

KK mice with spontaneous hereditary diabetes and human diabetic-like glomerulosclerosis were treated with either 0.5 or 2.5 mg/kg of glyburide, a sulfonylurea compound, from 2 months of age. Both, saline and glyburide-treated mice were sacrificed at 4, 6, 9, and 12 months of age, and their kidneys w...

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Veröffentlicht in:	Experimental and molecular pathology 1978-08, Vol.29 (1), p.92-101
Hauptverfasser:	Reddi, A.S., Oppermann, W., Patel, D.G., Ehrenreich, T., Camerini-Davalos, R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Diabetes Complications Diabetes Mellitus - blood Diabetes Mellitus - pathology Glomerulonephritis - etiology Glomerulosclerosis, Focal Segmental - etiology Glomerulosclerosis, Focal Segmental - pathology Glomerulosclerosis, Focal Segmental - prevention & control Glyburide - therapeutic use Insulin - blood Mice
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Zusammenfassung:	KK mice with spontaneous hereditary diabetes and human diabetic-like glomerulosclerosis were treated with either 0.5 or 2.5 mg/kg of glyburide, a sulfonylurea compound, from 2 months of age. Both, saline and glyburide-treated mice were sacrificed at 4, 6, 9, and 12 months of age, and their kidneys were examined by light microscopy. The data indicate that early glyburide treatment is effective in ameliorating or delaying the progression of diabetic glomerulosclerosis. This effect seems to be related to the early control of hyperglycemia in KK mice.
ISSN:	0014-4800 1096-0945
DOI:	10.1016/0014-4800(78)90029-1