Naloxone reversal of endotoxin hypotension suggests role of endorphins in shock

IT is known that the cardiovascular system is extremely sensitive to the effects of both exogenous 1,2 and endogenous 3 opiates. In rats, less than 1% of the morphine dose necessary to produce antinociception results in significant hypotension and brady-cardia 4 . The endogenous opiate β -endorphin is stored along with pituitary adrenocorticotrophin (ACTH) 5,6 , and the action of stressors seems to result in the release of both peptides 5,6 . Therefore, it seemed likely that β -endorphin is released during shock states and that it might contribute to the hypotension. To test this hypothesis we used an endotoxin shock model 7,8 . If endotoxin-induced hypotension were mediated through endorphin release, then blockade of endorphins should reverse such hypotension. Using the specific opiate antagonist, naloxone, we not only rapidly reversed endotoxin-induced hypotension, but also prophylactically blocked its occurrence. These findings suggest that endorphins may have a role in the patho-physiology of shock and that narcotic antagonists should be evaluated for their potential therapeutic value in the treatment of shock.